Roles
Clinical Professor
Vice Chair of Clinical and Translational Research
Co-Leader, Cancer Epigenetics Program, Sylvester Comprehensive Cancer Center
-
Biography
Dr. Lombard received his MD from Harvard Medical School, and his PhD at MIT, where he studied Werner syndrome and related progerias. After Pathology residency at the Brigham and Women’s Hospital in Boston, Dr. Lombard pursued postdoctoral work in the area of sirtuin biology, supported by an NIA/NIH K08 award. Dr. Lombard was the first to describe a central role for the sirtuin SIRT3 in regulating mitochondrial protein acetylation. He set up his independent lab at the University of Michigan in 2008, where he rose to the rank of tenured Associate Professor and directed the T32-supported Cancer Biology doctoral program.
Dr. Lombard’s research interests focus on the interrelationships between cancer, aging, and metabolism. He was named a New Scholar in Aging of the Ellison Medical Foundation, a member of The American Society for Clinical Investigation, a Scholar-Innovator of the Harrington Discovery Institute, and a recipient of an AACR Innovation and Discovery award. He serves a member of many NIH, DoD, and foundation review panels. Dr. Lombard joined the faculty of the DPLM and the Sylvester Comprehensive Cancer Center in the spring of 2022. He serves as Vice-Chair for Clinical and Translational Research at the DPLM, and Co-Leader of the Cancer Epigenetics program at the Sylvester. -
Education & Training
Education
Post Graduate Training
Licensures and Certifications
-
Honors & Awards
No result found
-
Teaching Interests
I strongly believe that it is the duty of those of us fortunate enough to engage in careers in biomedical research and patient care to “pay it forward”, by mentoring the next generation of clinicians and investigators. This is a value that I have tried to exemplify throughout my own career. In this regard, I have a deep and long-standing commitment to biomedical education. During my MD/PhD training, I had the privilege of serving as a resident premedical tutor at Dunster House, an undergraduate dormitory at Harvard College, for 11 years. During that time, I advised, and wrote institutional letters of support, for ~250 undergraduate premedical students.
Before recently departing the University of Michigan for the University of Miami, I served as Director of the Cancer Biology Graduate Program, and PI of the associated T32, T32CA009676. Prior to that time, I was Associate Director of this program, in charge of admissions. Our training program emphasized recruiting a highly accomplished and diverse body of trainees, and making them all feel welcomed and valued. I have mentored numerous PhD students and postdocs who have gone on to successful careers, and have served on dozens of dissertation committees. I have also taught dozens of residents and medical students in the context of my clinical speciality, molecular diagnostics. -
Research Interests
Our work focuses mainly on the sirtuin proteins, deacylases that promote longevity in budding yeast and other invertebrates, and homeostasis in mammals. Our current efforts primarily involve the sirtuin SIRT5. Ongoing work in the lab, supported by the NIH and DoD, focuses on how SIRT5 plays oncogenic roles in specific cancer types, such as melanoma and sarcoma, and attempts to develop small molecule SIRT5 inhibitors as new cancer medicines. Our group performs complementary studies in cultured cells and whole mice, using biochemical, transcriptomic, and metabolomic-based approaches. Other studies in the lab are focused on development of small molecules targeting processes relevant for stress resistance and aging. -
Publications
Disclaimer: The information presented in this section has been consolidated using AI and machine learning technologies. While every effort has been made to ensure accuracy, errors may occur. If you identify any inaccuracies, please use this link to inform our data team. Your feedback is greatly appreciated and helps us improve the quality of our content.
-
Professional Activities
No result found