Education
| 2020 | Post Doctoral Chemistry, Texas A&M University |
| 2018 | Post Doctoral Chemistry, National Institutes of Health |
| 2015 | Ph.D. Chemistry, Texas A&M University |
| 2010 | B.Sc. Pharmacy, Nankai University |
Professional Experience
| 2020 - | Assistant Professor of Chemistry, University of Miami |
RESEARCH INTERESTS
Our research interests lie broadly in organic chemistry, polymer chemistry, materials chemistry, chemical biology, drug delivery, and nanomedicine, with emphasis on the translation of polymer chemistry to functional nanomaterials designed for advanced disease treatment. The central theme of will involve the fundamental development of synthetic methodologies that allow for precise tuning of the chemical structures of both synthetic and biologic macromolecules, thereby modulating interactions between synthetic and biologic macromolecular constructs. We aim to develop new polymeric materials to address unmet needs in human health and sustainability, while simultaneously educating the next generation of scientists.Organic Chemistry, Polymer Chemistry, Drug Delivery, Nanomedicine
Publications
Lin, Y.N.; Khan, S.; Song, Y.; Dong, M.; Shen, Y.; Tran, D. K.; Pang, C.; Zhang, F.; Wooley, K. L. "A tale of drug-carrier optimization: Controlling stimuli sensitivity via nanoparticle hydrophobicity through drug loading" Nano Letter (2020).
Ni, Q.; Zhang, F.; Liu, Y.; Wang, Z.; Yu, G.; Liang, B.; Niu, G.; Su, T.; Zhu, G. Lu, G.; Zhang, L.; Chen, X. "A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer" Sci. Adv. (2020).
Yang, W.; Zhang, F. Deng, H.; Lin, L.; Wang, S. Kang, F.; Yu, G.; Lau, J.; Tian, R.; Zhang, M.; Wang, Z.; He, L.; Ma, Y.; Niu, G.; Hu, S.; Chen, X. "Smart nanovesicle mediated immunogenic cell death through tumor microenvironment modulation for effective photodynamic immunotherapy" ACS Nano (2020).
Zhang, F.; Ni, Q.; Jacobson, O.; Cheng, S.; Liao, A.; Wang, Z.; He, Z.; Yu, G.; Song, J.; Ma, Y.; Niu, G.; Zhang, L.; Zhu, G.; Chen, X. "Polymeric nanoparticles with glutathione-sensitive heterodimeric multifunctional prodrug for in vivo drug monitoring and synergistic cancer therapy" Angewandte Chemie International Edition (2018).
Ni, Q.; Zhang, F.; Zhang, Y.; Zhu, G.; Wang, Z.; Teng, Z.; Wang, C.; Yung, B. C.; Niu, G.; Lu, G.; Zhang, L.; Chen, X. "In situ shRNA synthesis on DNA–polylactide nanoparticles to treat multidrug resistant breast cancer" Advanced Materials (2018).
Zhang, F.; Zhu, G.; Jacobson, O.; Liu, Y.; Chen, K.; Yu, G.; Ni, Q.; Fan, J.; Yang, Z.; Xu. F.; Fu, X.; Wang, Z.; Ma, Y.; Niu, G.; Zhao, X.; Chen, X. "Transformative nanomedicine of an amphiphilic camptothecin prodrug for long circulation and high tumor uptake in cancer therapy" ACS Nano (2017).
Zhu, G.; Mei, L.;Vishwasrao, H.; Jacobson, O.; Liu, Y.; Wang, Z.; Yung, B.; Fu, X.; Jin, A.; Niu, G.; Wang, Q.; Zhang, F.; Shroff, H.; Chen, X. "Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy" Nature Communications (2017).
Zhang, F.; Khan, S.; Li, R.; Smolen, J. A.; Zhang, S.; Zhu, G.; Su, L.; Jahnke, A. A.; Elsabahy, M.; Chen, X.; Wooley, K. L. Nanoscale (2017).
Zhang, F.; Zhang, S.; Pollack, S. F.; Li, R.; Gonzalez, A. M.; Fan, J.; Zou, J.; Leininger, S. E.; Pavía-Sanders, A.; Johnson, R.; Nelson, L. D.; Raymond, J. E.; Elsabahy, M.; Hughes, D. M. P.; Lenox, M. W.; Gustafson, T. P.; Wooley, K. L. "Improving paclitaxel delivery: in vitro and in vivo characterization of PEGylated polyphosphoester-based nanocarriers" Journal of the American Chemical Society (2015).
Zhang, F.; Smolen, J. A.; Zhang, S.; Li, R.; Shah, P. N.; Cho, S.; Wang, H.; Raymond, J. E.; Cannon, C. L.; Wooley, K. L. "Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections" Nanoscale (2015).
