Francisco Raymo


(305) 284-2639
Locator Code:



1997-1999Post Doctoral University of California , Los Angeles
1996-1997Post Doctoral University of Birmingham ( UK )
1996Ph.D. University of Birmingham (UK)

Research within the Laboratory for Molecular Photonics is aimed at the identification of valuable strategies to manipulate molecules with photons and photons with molecules on the basis of absorption and emission processes.  The ultimate goal of these fundamental studies is the development of new phenomena and innovative materials for possible applications in biomedical research and information technology.  This experimental program demands the design and synthesis of inorganic nanoparticles, organic compounds and macromolecular constructs, their structural characterization and the investigation of their electrochemical, photochemical and photophysical properties.  In this context, the Laboratory for Molecular Photonics has already developed mechanisms to:
·   perform logic operations with photochromic compounds;
·   sense analytes with chromogenic and luminescent assemblies of inorganic nanoparticles and organic compounds;
·   self-assemble films of electrochromic building blocks on metallic electrodes;
·   design photochromic compounds with fast switching speeds and excellent fatigue resistances.
·   activate the luminescence of biocompatible quantum dots with optical stimulations.
Current research efforts are directed to the design of molecular strategies to overcome diffraction and permit the acquisition of fluorescence images with resolution at the nanometer level.  These fundamental investigations can ultimately lead to valuable analytical tools for the visualization of biological samples at the nanoscale with far-field optics and, therefore, can have a significant impact on biomedical research.  Specifically, the Laboratory for Molecular Photonics is in the process of developing experimental protocols to:

·         switch the emission of fluorescent probes under optical control.


Y. Zhang, K.-H. Song, S. Tang, L. Ravelo, J. Cusido, C. Sun, H. F. Zhang, F. M. Raymo Far-Red Photoactivatable BODIPYs for the Super-Resolution Imaging of Live Cells 12741–12745140 (J. Am. Chem. Soc.. 2018).

Y. Zhang, S. Tang, E. R. Thapaliya, L. Sansalone, F. M. Raymo Fluorescence Activation with Switchable Oxazines 8799–880954 (Chem. Commun.. 2018).

L. Sansalone, S. Tang, J. Garcia-Amorós, Y. Zhang, S. Nonell, J. D. Baker, B. Captain and F. M. Raymo A Photoactivatable Far-Red/Near-Infrared BODIPY to Monitor Cellular Dynamics in Vivo 1347–13533 (ACS Sens.. 2018).

E. R. Thapaliya, Y. Zhang, P. Dhakal, A. S. Brown, J. N. Wilson, K. M. Collins, F. M. Raymo Bright and Compact Macromolecular Probes for Bioimaging Applications 105070P-1–510507 (Proc. SPIE. 2018).

S. Tang, Y. Zhang, P. Dhakal, L. Ravelo, C. L. Anderson, K. M. Collins, F. M. Raymo Photochemical Barcodes 4485–4488140 (J. Am. Chem. Soc.. 2018).

X. Liu, Y. Zhang, J. D. Baker, F. M. Raymo A Photoactivatable Light Tracer 12714–127195 (J. Mater. Chem.. 2017).

N. Aibani, P. Fontoura da Costa, J. Masterson, N. Marino, F. M. Raymo, J. Callan, B. Callan The Integration of Triggered Drug Delivery with Real Time Quantification Using FRET; Creating a Super 'Smart' Drug Delivery System 136–144264 (J. Control. Rel.. 2017).

E. R. Thapaliya, F. M. Raymo, J. Garcia-Amorós Inorg. Chim. Acta 82–190468 (Fluorescence Activation with the Plasmonic Assistance of Silver Nanoparticles. 2017).

X. Ma, F. Tao, Y. Zhang, T. Li, F. M. Raymo, Y. Cui Detection of Nitroaromatic Explosives by 3D Hyperbranched – Conjugated Polymer on the Basis of the POSS Scaffold 14343–143545 (J. Mater. Chem.. 2017).

K. Li, Y. Zhang, B. Qiao, F. Tao, T. Li, Y. Ding, F. M. Raymo, Y. Cui RSC Adv. 30229–302417 (Facile Fabrication of AIE/AIEE-Active Fluorescent 1 Nanoparticles Based on Barbituric for Cell Imaging Applications. 2017).

E. R. Thapaliya, Y. Zhang, P. Dhakal, A. S. Brown, J. N. Wilson, K. M. Collins, F. M. Raymo Bioimaging with Macromolecular Probes Incorporating Multiple BODIPY Fluorophores 1519–152828 (Bioconjugate Chem.. 2017).

E. R. Thapaliya, J. Garcia-Amorós, S. Nonell, B. Captain, F. M. Raymo Structural Implications on the Excitation Dynamics of Fluorescent 3H-Indolium Cations 11904–1191319 (Phys. Chem. Chem. Phys.. 2017).

A. Pietropaolo, S. Tang, F. M. Raymo Free-Energy Predictions and Absorption Spectra Calculations for Supramolecular Nanocarriers and Their Photoactive Cargo 4989–49949 (Nanoscale. 2017).

E. R. Thapaliya, C. Fowley, B. Callan, S. Tang, Y. Zhang, J. F. Callan, F. M. Raymo Probing the Intracellular Fate of Supramolecular Nanocarriers and Their Cargo with FRET Schemes 10078B-1–810078 (Proc. SPIE. 2017).

Y. Zhang, S. Tang, L. Sansalone, E. R. Thapaliya, J. D. Baker, F. M. Raymo Supramolecular Delivery of Photoactivatable Fluorophores in Developing Embryos 10078A-1–610078 (Proc. SPIE. 2017).

Y. Zhang, S. Tang, E. R. Thapaliya, F. M. Raymo Highlighting Cancer Cells with Macromolecular Probes 1007814-1–610078 (Proc. SPIE. 2017).

S. Tang, Y. Zhang, E. R. Thapaliya, A. Brown, J. N. Wilson, F. M. Raymo Highlighting Cancer Cells with Halochromic Switches 92–1012 (ACS Sensors. 2017).

Fluorescence Patterning with Mild Illumination in Polymer Films of Photocleavable Oxazines 1179–11835 (J. Mater. Chem. C. ).